With the rapid acceptance and increased use of negative pressure therapy in foot wounds, it is important to understand this new science. Dr. Armstrong provides a structured approach to explore the indications, mechanism of action, and application of VAC therapy in various wound types. Detailed discussion will take you step by step through the components of the VAC therapy system and the proper way in which they are applied. The lecture begins with a presentation of diabetic foot wound epidemiology to form the background for many of the discussion points. Emphasis is placed on the significant rates of contralateral amputation and death which frequently follow a limb loss in a patient with diabetes. Several case discussions are used to highlight the practical points of negative pressure wound therapy in various wound types and etiologies. The role of VAC therapy in conjunction with split thickness skin grafting and other adjunctive procedures is presented.