Every podiatrist will sometime in their career have a patient with an ulcer that just won't heal. The reason that the chronic wound exists is discussed in this lecture by Dr. Driver. The lecture discusses the balance between cytokines and growth factors in wound healing. She also talks of the role that matrix metalloproteases play in chronic ulcers, and the wound care products such as Promogram and Regranex that can jump start a chronic wound into a healing wound.