This lecture by Dr. William Tamborlane, MD describes the potential benefits of real-time continuous glucose monitoring (RT-CGM) in the management of patients with type 1 diabetes (T1D). It reviews the evidence from randomized clinical trials that has been incorporated into the American Diabetes Association guidelines for use of these devices in clinical practice. Recent studies have also demonstrated improved outcomes when CGM is combined with insulin pump therapy in patients who are unable to achieve target A1c levels with glargine-based multiple daily injection regimens.