The controversial topic of patient non-compliance is explored in-depth in this lecture. Many of the diverse etiologies that have been identified are discussed and the more common ones are explored in case-study format, based on actual cases. Methods for overcoming patient non-compliance are discussed as well as the significant impact that this activity has on the medical system. After viewing this lecture, the student will be able to identify non-compliance in his patients and implement methods to successfully overcome that destructive behavior.