Evidence Based Medicine has become a dominant term in research and clinical practice over the past decade. It is likely that you have at least heard of Evidence Based Medicine (EBM), and as a resident you are probably being told to utilize EBM principles in your decision making and when critiquing a journal article. However, do you really know the definition of EBM and how it relates to biostatistics, epidemiology, and the levels of evidence in a given study? What do sensitivity, specificity, and +/- predictive values really mean to you and your patient?